http://www.mecprolabs.com
GW501516,alsoknownasGW-501,516,GW1516orGSK-516isaPPAR***948…
http://www.mecprolabs.com
GW501516,alsoknownasGW-501,516,GW1516orGSK-516isaPPAR***948;modulatorcompoundbeinginvestigatedfordruguse.Itactivatesthesamepathwaysactivatedthroughexercise,includingPPAR***948;andAMP-activatedproteinkinase.GW501516isbeinginvestigatedasapotentialtreatmentforobesity,diabetes,dyslipidemiaandcardiovasculardisease.GW-501516hasasynergisticeffectwhencombinedwithAICAR:thecombinationhasbeenshowntosignificantlyincreaseexerciseenduranceinanimalstudiesmorethaneithercompoundalone.
GW501516regulatesfatburningthroughanumberofwidespreadmechanisms;GW501516increasesglucoseuptakeinskeletalmuscletissueandincreasesmusclegeneexpression,especiallygenesinvolvedinpreferentiallipidutilization.,Thisshiftchangesthebody’smetabolismtofavorburningfatforenergyinsteadofcarbohydratesormuscleprotein,potentiallyallowingclinicalapplicationforobesepatientstolosefateffectivelywithoutexperiencingmusclecatabolismortheeffectsandsatietyissuesassociatedwithlowbloodsugar.GW-501516alsoincreasesmusclemass,whichimprovedglucosetoleranceandreducedfatmassaccumulationeveninmicefedaveryhighfatdiet,suggestingthatGW-501516mayhaveaprotectiveeffectagainstobesity.